THE XIN JIE CHEN LABORATORY

The main goal of our laboratory is to learn how mitochondrial damage causes cellular stress, and affects cell fitness and organismal survival. We are particularly interested to learn whether mitochondrial Precursor Overaccumulation Stress (mPOS), a novel cell stress mechanism that we recently discovered, contributes to cell degeneration and affects tissue function in aging-related degenerative diseases. We use yeast, cultured human cells and mouse models in our studies.